Reaction Details |
| Report a problem with these data |
Target | Interstitial collagenase |
---|
Ligand | BDBM50118986 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_106290 |
---|
IC50 | 55±n/a nM |
---|
Citation | Nelson, FC; Delos Santos, E; Levin, JI; Chen, JM; Skotnicki, JS; DiJoseph, JF; Sharr, MA; Sung, A; Killar, LM; Cowling, R; Jin, G; Roth, CE; Albright, JD Benzodiazepine inhibitors of the MMPs and TACE. Bioorg Med Chem Lett12:2867-70 (2002) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Interstitial collagenase |
---|
Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
|
|
|
BDBM50118986 |
---|
n/a |
---|
Name | BDBM50118986 |
Synonyms: | 1-(5-Fluoro-2-methyl-benzoyl)-4-(4-methoxy-benzenesulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | CHEMBL97962 |
Type | Small organic molecule |
Emp. Form. | C25H24FN3O6S |
Mol. Mass. | 513.538 |
SMILES | COc1ccc(cc1)S(=O)(=O)N1Cc2ccccc2N(CC1C(=O)NO)C(=O)c1cc(F)ccc1C |
Structure |
|