| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Interstitial collagenase |
|---|
| Ligand | BDBM50118979 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_106290 |
|---|
| IC50 | 841±n/a nM |
|---|
| Citation |  Nelson, FC; Delos Santos, E; Levin, JI; Chen, JM; Skotnicki, JS; DiJoseph, JF; Sharr, MA; Sung, A; Killar, LM; Cowling, R; Jin, G; Roth, CE; Albright, JD Benzodiazepine inhibitors of the MMPs and TACE. Bioorg Med Chem Lett12:2867-70 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Interstitial collagenase |
|---|
| Name: | Interstitial collagenase |
|---|
| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54010.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03956 |
|---|
| Residue: | 469 |
|---|
| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
|
|
|
|---|
| BDBM50118979 |
|---|
| n/a |
|---|
| Name | BDBM50118979 |
|---|
| Synonyms: | 4-(4-But-2-ynyloxy-benzenesulfonyl)-1-cyclopropanecarbonyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | CHEMBL95460 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H25N3O6S |
|---|
| Mol. Mass. | 483.537 |
|---|
| SMILES | CC#CCOc1ccc(cc1)S(=O)(=O)N1Cc2ccccc2N(CC1C(=O)NO)C(=O)C1CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
