| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 3 |
|---|
| Ligand | BDBM50204253 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2064689 (CHEMBL4719942) |
|---|
| IC50 | 110±n/a nM |
|---|
| Citation |  Chappell, MD; Li, R; Smith, SC; Dressman, BA; Tromiczak, EG; Tripp, AE; Blanco, MJ; Vetman, T; Quimby, SJ; Matt, J; Britton, TC; Fivush, AM; Schkeryantz, JM; Mayhugh, D; Erickson, JA; Bures, MG; Jaramillo, C; Carpintero, M; Diego, JE; Barberis, M; Garcia-Cerrada, S; Soriano, JF; Antonysamy, S; Atwell, S; MacEwan, I; Condon, B; Sougias, C; Wang, J; Zhang, A; Conners, K; Groshong, C; Wasserman, SR; Koss, JW; Witkin, JM; Li, X; Overshiner, C; Wafford, KA; Seidel, W; Wang, XS; Heinz, BA; Swanson, S; Catlow, JT; Bedwell, DW; Monn, JA; Mitch, CH; Ornstein, PL Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity. J Med Chem59:10974-10993 (2016) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 3 |
|---|
| Name: | Metabotropic glutamate receptor 3 |
|---|
| Synonyms: | GPRC1C | GRM3 | GRM3_HUMAN | MGLUR3 | metabotropic glutamate 3 | metabotropic glutamate 3/1a | metabotropic glutamate 3/1c |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 98889.09 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | metabotropic glutamate 1c 0 HUMAN::Q14832 |
|---|
| Residue: | 879 |
|---|
| Sequence: | MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS
DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY
LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK
HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA
EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH
LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
|
|
|
|---|
| BDBM50204253 |
|---|
| n/a |
|---|
| Name | BDBM50204253 |
|---|
| Synonyms: | CHEMBL3956934 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H15ClFNO4 |
|---|
| Mol. Mass. | 327.735 |
|---|
| SMILES | [H][C@@]12C[C@@H](Cc3ccc(F)c(Cl)c3)[C@@](N)(C(O)=O)[C@]1([H])[C@H]2C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
