| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 3 |
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| Ligand | BDBM50558768 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2064695 (CHEMBL4719948) |
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| Ki | 4.5±n/a nM |
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| Citation |  Chappell, MD; Li, R; Smith, SC; Dressman, BA; Tromiczak, EG; Tripp, AE; Blanco, MJ; Vetman, T; Quimby, SJ; Matt, J; Britton, TC; Fivush, AM; Schkeryantz, JM; Mayhugh, D; Erickson, JA; Bures, MG; Jaramillo, C; Carpintero, M; Diego, JE; Barberis, M; Garcia-Cerrada, S; Soriano, JF; Antonysamy, S; Atwell, S; MacEwan, I; Condon, B; Sougias, C; Wang, J; Zhang, A; Conners, K; Groshong, C; Wasserman, SR; Koss, JW; Witkin, JM; Li, X; Overshiner, C; Wafford, KA; Seidel, W; Wang, XS; Heinz, BA; Swanson, S; Catlow, JT; Bedwell, DW; Monn, JA; Mitch, CH; Ornstein, PL Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity. J Med Chem59:10974-10993 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 3 |
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| Name: | Metabotropic glutamate receptor 3 |
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| Synonyms: | GPRC1C | GRM3 | GRM3_HUMAN | MGLUR3 | metabotropic glutamate 3 | metabotropic glutamate 3/1a | metabotropic glutamate 3/1c |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 98889.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | metabotropic glutamate 1c 0 HUMAN::Q14832 |
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| Residue: | 879 |
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| Sequence: | MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS
DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY
LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK
HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA
EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH
LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
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| BDBM50558768 |
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| n/a |
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| Name | BDBM50558768 |
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| Synonyms: | CHEMBL4759992 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20ClFN4O4S2 |
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| Mol. Mass. | 474.957 |
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| SMILES | Cl.[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](CSc1ccc(F)c(C)c1)[C@H]2Sc1nc[nH]n1)C(O)=O |r| |
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| Structure | 
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