Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Gonadotropin-releasing hormone receptor | ||
Ligand | BDBM50121081 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_71749 | ||
Ki | 270±n/a nM | ||
Citation | Luthin, DR; Hong, Y; Pathak, VP; Paderes, G; Nared-Hood, KD; Castro, MA; Vazir, H; Li, H; Tompkins, E; Christie, L; May, JM; Anderson, MB The discovery of novel small molecule non-peptide gonadotropin releasing hormone (GnRH) receptor antagonists. Bioorg Med Chem Lett12:3467-70 (2002) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Gonadotropin-releasing hormone receptor | |||
Name: | Gonadotropin-releasing hormone receptor | ||
Synonyms: | GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr | ||
Type: | PROTEIN | ||
Mol. Mass.: | 37767.60 | ||
Organism: | Rattus norvegicus | ||
Description: | ChEMBL_1335047 | ||
Residue: | 327 | ||
Sequence: |
| ||
BDBM50121081 | |||
n/a | |||
Name | BDBM50121081 | ||
Synonyms: | 5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-furan-2-carboxylic acid (4-carbamoyl-cyclohexylmethyl)-amide | CHEMBL117863 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H40N2O3 | ||
Mol. Mass. | 464.6395 | ||
SMILES | Cc1cc2c(cc1Cc1ccc(o1)C(=O)NC[C@H]1CC[C@@H](CC1)C(N)=O)C(C)(C)CCC2(C)C |wU:20.25,wD:17.18,(9.62,-7.31,;8.27,-6.52,;6.94,-7.29,;5.61,-6.52,;5.61,-4.98,;6.94,-4.21,;8.27,-4.98,;9.62,-4.21,;9.62,-2.67,;10.78,-1.63,;10.16,-.24,;8.62,-.4,;8.29,-1.9,;7.61,.77,;6.1,.47,;8.1,2.22,;7.09,3.38,;5.58,3.08,;4.56,4.25,;3.06,3.96,;2.57,2.49,;3.57,1.33,;5.07,1.63,;1.05,2.19,;.03,3.33,;.56,.72,;4.28,-4.21,;5.61,-3.44,;2.94,-3.44,;2.94,-4.98,;2.94,-6.52,;4.28,-7.29,;5.37,-8.38,;2.78,-7.7,)| | ||
Structure |