Ki Summary

Reaction Details

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Target

Gonadotropin-releasing hormone receptor

Ligand

BDBM50121090

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_71598

16±n/a nM

Citation

Luthin, DR; Hong, Y; Pathak, VP; Paderes, G; Nared-Hood, KD; Castro, MA; Vazir, H; Li, H; Tompkins, E; Christie, L; May, JM; Anderson, MB The discovery of novel small molecule non-peptide gonadotropin releasing hormone (GnRH) receptor antagonists. Bioorg Med Chem Lett12:3467-70 (2002) [PubMed]

More Info.:

Get all data from this article, Assay Method

Gonadotropin-releasing hormone receptor

Name:

Gonadotropin-releasing hormone receptor

Synonyms:

Type:

Enzyme

Mol. Mass.:

37749.45

Organism:

Homo sapiens (Human)

Description:

P30968

Residue:

328

Sequence:

MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL

BDBM50121090

n/a

Name

BDBM50121090

Synonyms:

5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-furan-2-carboxylic acid (4-guanidinomethyl-cyclohexylmethyl)-amide | CHEMBL115482

Type

Small organic molecule

Emp. Form.

C30H44N4O2

Mol. Mass.

492.696

SMILES

Cc1cc2c(cc1Cc1ccc(o1)C(=O)NC[C@H]1CC[C@H](CNC(N)=N)CC1)C(C)(C)CCC2(C)C |wU:20.22,wD:17.18,(13.73,-14.94,;12.37,-14.16,;11.04,-14.93,;9.71,-14.16,;9.71,-12.62,;11.04,-11.85,;12.37,-12.62,;13.73,-11.85,;13.73,-10.31,;14.89,-9.27,;14.26,-7.89,;12.72,-8.03,;12.4,-9.54,;11.71,-6.87,;10.2,-7.17,;12.21,-5.42,;11.2,-4.25,;9.69,-4.56,;8.68,-3.39,;7.17,-3.67,;6.67,-5.14,;5.16,-5.46,;4.14,-4.3,;4.63,-2.85,;3.6,-1.7,;6.12,-2.54,;7.68,-6.31,;9.18,-6,;8.38,-11.85,;7.05,-11.08,;9.71,-11.08,;7.05,-12.62,;7.05,-14.16,;8.38,-14.93,;9.48,-16.01,;6.89,-15.34,)|

Structure