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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Gonadotropin-releasing hormone receptor | ||
| Ligand | BDBM50121104 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_71598 | ||
| Ki | 250±n/a nM | ||
| Citation |  Luthin, DR; Hong, Y; Pathak, VP; Paderes, G; Nared-Hood, KD; Castro, MA; Vazir, H; Li, H; Tompkins, E; Christie, L; May, JM; Anderson, MB The discovery of novel small molecule non-peptide gonadotropin releasing hormone (GnRH) receptor antagonists. Bioorg Med Chem Lett12:3467-70 (2002) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Gonadotropin-releasing hormone receptor | |||
| Name: | Gonadotropin-releasing hormone receptor | ||
| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 37749.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P30968 | ||
| Residue: | 328 | ||
| Sequence: |
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| BDBM50121104 | |||
| n/a | |||
| Name | BDBM50121104 | ||
| Synonyms: | 4-({[5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-furan-2-carbonyl]-amino}-methyl)-cyclohexanecarboxylic acid | CHEMBL323687 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H39NO4 | ||
| Mol. Mass. | 465.6243 | ||
| SMILES | Cc1cc2c(cc1Cc1ccc(o1)C(=O)NC[C@H]1CC[C@@H](CC1)C(O)=O)C(C)(C)CCC2(C)C |wU:20.25,wD:17.18,(8.87,-7.01,;7.54,-6.23,;6.19,-7,;4.86,-6.23,;4.86,-4.69,;6.19,-3.92,;7.54,-4.69,;8.87,-3.92,;8.89,-2.38,;10.04,-1.34,;9.41,.05,;7.89,-.1,;7.56,-1.61,;6.87,1.07,;5.35,.76,;7.36,2.51,;6.35,3.68,;4.84,3.38,;3.83,4.54,;2.32,4.26,;1.83,2.79,;2.83,1.63,;4.32,1.93,;.31,2.47,;-.18,1.02,;-.72,3.63,;3.53,-3.92,;4.88,-3.15,;2.2,-3.15,;2.2,-4.69,;2.2,-6.23,;3.53,-7,;4.63,-8.08,;2.04,-7.4,)| | ||
| Structure | 
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