| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Progesterone receptor |
|---|
| Ligand | BDBM50121166 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_159533 (CHEMBL767566) |
|---|
| IC50 | 38±n/a nM |
|---|
| Citation |  Fensome, A; Bender, R; Cohen, J; Collins, MA; Mackner, VA; Miller, LL; Ullrich, JW; Winneker, R; Wrobel, J; Zhang, P; Zhang, Z; Zhu, Y New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles. Bioorg Med Chem Lett12:3487-90 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Progesterone receptor |
|---|
| Name: | Progesterone receptor |
|---|
| Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 98979.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06401 |
|---|
| Residue: | 933 |
|---|
| Sequence: | MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
|
|
|
|---|
| BDBM50121166 |
|---|
| n/a |
|---|
| Name | BDBM50121166 |
|---|
| Synonyms: | 5'-(3-nitrophenyl)spiro[cyclopentane-1,3'-indol]-2'(1'H)-one | CHEMBL419057 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H16N2O3 |
|---|
| Mol. Mass. | 308.3312 |
|---|
| SMILES | [O-][N+](=O)c1cccc(c1)-c1ccc2NC(=O)C3(CCCC3)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
