Ki Summary

Reaction Details

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Target

Reverse transcriptase/RNaseH

Ligand

BDBM50121357

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_195204 (CHEMBL798996)

IC50

4120±n/a nM

Citation

Barreca, ML; Balzarini, J; Chimirri, A; De Clercq, E; De Luca, L; Höltje, HD; Höltje, M; Monforte, AM; Monforte, P; Pannecouque, C; Rao, A; Zappalà, M Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents. J Med Chem45:5410-3 (2002) [PubMed]

More Info.:

Get all data from this article, Assay Method

Reverse transcriptase/RNaseH

Name:

Reverse transcriptase/RNaseH

Synonyms:

HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH

Type:

PROTEIN

Mol. Mass.:

65229.15

Organism:

Human immunodeficiency virus 1

Description:

ChEMBL_1473730

Residue:

566

Sequence:

PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID

BDBM50121357

n/a

Name

BDBM50121357

Synonyms:

2-(2,6-Difluoro-phenyl)-3-(4,6-dimethyl-pyridin-2-yl)-thiazolidin-4-one | 2-(2,6-Difluorophenyl)-3-(4,6-dimethylpyridin-2-yl)-l,3-thiazolidin-4-one | 2-(2,6-difluorophenyl)-3-(4,6-dimethylpyridin-2-yl)thiazolidin-4-one | CHEMBL150025

Type

Small organic molecule

Emp. Form.

C16H14F2N2OS

Mol. Mass.

320.357

SMILES

Cc1cc(C)nc(c1)N1C(SCC1=O)c1c(F)cccc1F

Structure