| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor beta |
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| Ligand | BDBM50121586 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_67203 (CHEMBL838887) |
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| Ki | 170±n/a nM |
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| Citation |  Henke, BR; Consler, TG; Go, N; Hale, RL; Hohman, DR; Jones, SA; Lu, AT; Moore, LB; Moore, JT; Orband-Miller, LA; Robinett, RG; Shearin, J; Spearing, PK; Stewart, EL; Turnbull, PS; Weaver, SL; Williams, SP; Wisely, GB; Lambert, MH A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta. J Med Chem45:5492-505 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor beta |
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| Name: | Estrogen receptor beta |
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| Synonyms: | ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta |
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| Type: | Protein |
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| Mol. Mass.: | 59238.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92731 |
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| Residue: | 530 |
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| Sequence: | MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
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| BDBM50121586 |
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| n/a |
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| Name | BDBM50121586 |
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| Synonyms: | 6-[4-(4-Methyl-piperazin-1-yl)-6-(3-phenyl-propylamino)-[1,3,5]triazin-2-ylamino]-5,6,7,8-tetrahydro-naphthalen-2-ol | CHEMBL153303 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H35N7O |
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| Mol. Mass. | 473.6131 |
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| SMILES | CN1CCN(CC1)c1nc(NCCCc2ccccc2)nc(NC2CCc3cc(O)ccc3C2)n1 |
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| Structure | 
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