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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Indoleamine 2,3-dioxygenase 1 | ||
| Ligand | BDBM50559672 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2069927 (CHEMBL4725180) | ||
| IC50 | 3.0±n/a nM | ||
| Citation |  Zhang, L; Cherney, EC; Zhu, X; Lin, TA; Gullo-Brown, J; Maley, D; Johnston-Allegretto, K; Kopcho, L; Fereshteh, M; Huang, C; Li, X; Traeger, SC; Dhar, G; Anandam, A; Mahankali, S; Padmanabhan, S; Rajanna, P; Murali, V; Mariappan, T; Borzilleri, R; Vite, G; Hunt, JT; Balog, A Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy. ACS Med Chem Lett12:494-501 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Indoleamine 2,3-dioxygenase 1 | |||
| Name: | Indoleamine 2,3-dioxygenase 1 | ||
| Synonyms: | I23O1_MOUSE | IDO-1 | Ido | Ido1 | Indo | Indoleamine-pyrrole 2,3-dioxygenase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 45639.39 | ||
| Organism: | Mus musculus | ||
| Description: | ChEMBL_1452149 | ||
| Residue: | 407 | ||
| Sequence: |
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| BDBM50559672 | |||
| n/a | |||
| Name | BDBM50559672 | ||
| Synonyms: | CHEMBL4750211 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H25ClFN3 | ||
| Mol. Mass. | 421.938 | ||
| SMILES | [H][C@]1(CC[C@@H](CC1)c1ccnc2ccc(F)cc12)C(CC)c1nc2ccc(Cl)cc2[nH]1 |r,wU:4.7,wD:1.0,(4.71,-8.61,;6.22,-8.87,;4.89,-9.64,;4.89,-11.19,;6.22,-11.96,;7.56,-11.19,;7.56,-9.64,;6.22,-13.51,;4.89,-14.28,;4.89,-15.82,;6.23,-16.59,;7.56,-15.82,;8.88,-16.59,;10.22,-15.82,;10.23,-14.27,;11.56,-13.49,;8.88,-13.51,;7.56,-14.27,;6.22,-7.32,;4.89,-6.55,;4.89,-5.02,;7.56,-6.56,;7.56,-5.01,;9.02,-4.53,;9.65,-3.12,;11.18,-2.96,;12.08,-4.21,;13.62,-4.03,;11.45,-5.61,;9.92,-5.78,;9.02,-7.02,)| | ||
| Structure | 
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