| Reaction Details |
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 | Report a problem with these data |
| Target | N-formyl peptide receptor 2 |
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| Ligand | BDBM50559840 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2070440 (CHEMBL4725974) |
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| EC50 | 0.290000±n/a nM |
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| Citation |  Asahina, Y; Wurtz, NR; Arakawa, K; Carson, N; Fujii, K; Fukuchi, K; Garcia, R; Hsu, MY; Ishiyama, J; Ito, B; Kick, E; Lupisella, J; Matsushima, S; Ohata, K; Ostrowski, J; Saito, Y; Tsuda, K; Villarreal, F; Yamada, H; Yamaoka, T; Wexler, R; Gordon, D; Kohno, Y Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure. J Med Chem63:9003-9019 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-formyl peptide receptor 2 |
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| Name: | N-formyl peptide receptor 2 |
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| Synonyms: | ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 38968.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25090 |
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| Residue: | 351 |
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| Sequence: | METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVT
TICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIA
LDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNF
ASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPL
RVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPM
LYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
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| BDBM50559840 |
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| n/a |
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| Name | BDBM50559840 |
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| Synonyms: | CHEMBL4760897 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14ClF2N3O3S |
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| Mol. Mass. | 401.815 |
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| SMILES | COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1 |r| |
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| Structure | 
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