Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50122392 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_124486 |
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IC50 | 44±n/a nM |
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Citation | Stelmach, JE; Liu, L; Patel, SB; Pivnichny, JV; Scapin, G; Singh, S; Hop, CE; Wang, Z; Strauss, JR; Cameron, PM; Nichols, EA; O'Keefe, SJ; O'Neill, EA; Schmatz, DM; Schwartz, CD; Thompson, CM; Zaller, DM; Doherty, JB Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase. Bioorg Med Chem Lett13:277-80 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50122392 |
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n/a |
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Name | BDBM50122392 |
Synonyms: | 1-(2,6-Dichloro-phenyl)-2-oxo-5-p-tolyl-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid methyl ester | CHEMBL97579 | methyl 1-(2,6-dichlorophenyl)-2-oxo-5-p-tolyl-1,2,3,4-tetrahydroquinazoline-7-carboxylate |
Type | Small organic molecule |
Emp. Form. | C23H18Cl2N2O3 |
Mol. Mass. | 441.307 |
SMILES | COC(=O)c1cc2N(C(=O)NCc2c(c1)-c1ccc(C)cc1)c1c(Cl)cccc1Cl |
Structure |
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