| Reaction Details |
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 | Report a problem with these data |
| Target | STE20/SPS1-related proline-alanine-rich protein kinase |
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| Ligand | BDBM50350105 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2072182 (CHEMBL4727716) |
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| IC50 | 4500±n/a nM |
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| Citation |  Fujii, S; Kikuchi, E; Watanabe, Y; Suzuyama, H; Ishigami-Yuasa, M; Mori, T; Isobe, K; Uchida, S; Kagechika, H Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| STE20/SPS1-related proline-alanine-rich protein kinase |
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| Name: | STE20/SPS1-related proline-alanine-rich protein kinase |
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| Synonyms: | DCHT | SPAK | STK39 | STK39_HUMAN | Serine/threonine-protein kinase 39 | Ste-20-related kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59471.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774551 |
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| Residue: | 545 |
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| Sequence: | MAEPSGSPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICR
DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN
VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL
DYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMA
PEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDK
EMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQR
AKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSAS
TIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVLRLRNSRKELNDIRFEFTPGRDTAD
GVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFA
QLSVS
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| BDBM50350105 |
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| n/a |
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| Name | BDBM50350105 |
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| Synonyms: | CHEMBL1814047 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H12Cl3NO3 |
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| Mol. Mass. | 408.662 |
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| SMILES | Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Oc2ccccc2)c(Cl)c1 |
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| Structure | 
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