| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid hormone receptor |
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| Ligand | BDBM50123059 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210505 |
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| Ki | 0.370000±n/a nM |
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| Citation |  Dow RL; Schneider SR; Paight ES; Hank RF; Chiang P; Cornelius P; Lee E; Newsome WP; Swick AG; Spitzer J; Hargrove DM; Patterson TA; Pandit J; Chrunyk BA; LeMotte PK; Danley DE; Rosner MH; Ammirati MJ; Simons SP; Schulte GK; Tate BF; DaSilva-Jardine P Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics. Bioorg Med Chem Lett 13:379-82 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyroid hormone receptor |
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| Name: | Thyroid hormone receptor |
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| Synonyms: | Nuclear receptor subfamily 1 group A member 2 | Thyroid hormone receptor | Thyroid hormone receptor beta |
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| Type: | Receptor |
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| Mol. Mass.: | 52793.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
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| Residue: | 461 |
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| Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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| BDBM50123059 |
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| n/a |
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| Name | BDBM50123059 |
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| Synonyms: | 2-{4-[3-(2-Aza-bicyclo[2.2.1]heptane-2-carbonyl)-4-hydroxy-phenoxy]-3,5-dichloro-phenyl}-2H-[1,2,4]triazine-3,5-dione | CHEMBL338602 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18Cl2N4O5 |
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| Mol. Mass. | 489.308 |
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| SMILES | Oc1ccc(Oc2c(Cl)cc(cc2Cl)-n2ncc(=O)[nH]c2=O)cc1C(=O)N1CC2CCC1C2 |
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| Structure | 
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