| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid hormone receptor alpha |
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| Ligand | BDBM50123052 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_210487 |
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| EC50 | 1500±n/a nM |
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| Citation |  Dow, RL; Schneider, SR; Paight, ES; Hank, RF; Chiang, P; Cornelius, P; Lee, E; Newsome, WP; Swick, AG; Spitzer, J; Hargrove, DM; Patterson, TA; Pandit, J; Chrunyk, BA; LeMotte, PK; Danley, DE; Rosner, MH; Ammirati, MJ; Simons, SP; Schulte, GK; Tate, BF; DaSilva-Jardine, P Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics. Bioorg Med Chem Lett13:379-82 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyroid hormone receptor alpha |
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| Name: | Thyroid hormone receptor alpha |
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| Synonyms: | C-erbA-alpha | EAR-7 | EAR7 | ERBA1 | NR1A1 | Nuclear receptor subfamily 1 group A member 1 | THA_HUMAN | THRA | THRA1 | THRA2 | Thyroid Hormone Receptor (TR-alpha) | Thyroid hormone receptor | Thyroid hormone receptor alpha | Thyroid hormone receptor apha | c-erbA-1 |
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| Type: | Receptor |
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| Mol. Mass.: | 54818.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRalpha 1. |
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| Residue: | 490 |
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| Sequence: | MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP
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| BDBM50123052 |
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| n/a |
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| Name | BDBM50123052 |
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| Synonyms: | 2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxolane]-8-ylsulfonyl}-4-hydroxyphenoxy)-3,5-dichlorophenyl]-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione | 2-{3,5-dichloro-4-[4-hydroxy-3-spiro[8-azabicyclo[3.2.1]octane-3,2'-(tetrahydrofuran)]-8-ylsulfonylphenoxy]phenyl}-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione | CHEMBL125946 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24Cl2N4O7S |
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| Mol. Mass. | 595.452 |
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| SMILES | Oc1ccc(Oc2c(Cl)cc(cc2Cl)-n2ncc(=O)[nH]c2=O)cc1S(=O)(=O)N1C2CCC1CC1(CCCO1)C2 |TLB:34:33:27:29.30,THB:24:27:33.38.32:29.30,37:33:27:29.30| |
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| Structure | 
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