Reaction Details |
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Target | Geranylgeranyl transferase type-1 subunit beta |
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Ligand | BDBM50127320 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_71806 |
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IC50 | 830±n/a nM |
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Citation | Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability. Bioorg Med Chem Lett13:1571-4 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Geranylgeranyl transferase type-1 subunit beta |
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Name: | Geranylgeranyl transferase type-1 subunit beta |
Synonyms: | 2.5.1.59 | GGTase-I-beta | Geranylgeranyl transferase type I | Geranylgeranyl transferase type I beta subunit | Geranylgeranyl transferase type I subunit beta | Geranylgeranyl transferase type-1 subunit beta | PGGT1B | PGTB1_HUMAN | Protein farnesyl/geranylgeranyl transferase | Type I protein geranyl-geranyltransferase subunit beta |
Type: | n/a |
Mol. Mass.: | 42369.84 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 377 |
Sequence: | MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
WKTKDSKQCSENVHIST
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BDBM50127320 |
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n/a |
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Name | BDBM50127320 |
Synonyms: | 5'-(3-Chloro-phenyl)-6'-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-4-hydroxy-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile | CHEMBL38941 |
Type | Small organic molecule |
Emp. Form. | C30H27ClN6O2 |
Mol. Mass. | 539.027 |
SMILES | Cn1cncc1C(OCc1nc(N2CCC(O)CC2)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N |
Structure |
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