| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50563422 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2082484 (CHEMBL4738275) |
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| Ki | 6.3±n/a nM |
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| Citation |  Ortiz Zacarķas, NV; Chahal, KK; ?imkovį, T; van der Horst, C; Zheng, Y; Inoue, A; Theunissen, E; Mallee, L; van der Es, D; Louvel, J; IJzerman, AP; Handel, TM; Kufareva, I; Heitman, LH Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2. J Med Chem64:2608-2621 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50563422 |
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| n/a |
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| Name | BDBM50563422 |
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| Synonyms: | CHEMBL4760108 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H12Cl3NO5S |
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| Mol. Mass. | 472.726 |
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| SMILES | OC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 |
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| Structure | 
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