| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
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| Ligand | BDBM50563426 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2082511 (CHEMBL4738302) |
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| IC50 | 5012±n/a nM |
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| Citation |  Ortiz Zacarķas, NV; Chahal, KK; ?imkovį, T; van der Horst, C; Zheng, Y; Inoue, A; Theunissen, E; Mallee, L; van der Es, D; Louvel, J; IJzerman, AP; Handel, TM; Kufareva, I; Heitman, LH Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2. J Med Chem64:2608-2621 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 1 |
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| Name: | C-C chemokine receptor type 1 |
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| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41180.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32246 |
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| Residue: | 355 |
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| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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| BDBM50563426 |
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| n/a |
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| Name | BDBM50563426 |
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| Synonyms: | CHEMBL4783861 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H16Cl2F3N3O4S2 |
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| Mol. Mass. | 590.422 |
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| SMILES | FC(F)(F)c1cc(ccc1Cl)S(=O)(=O)Nc1cc(Cl)ccc1Oc1ccc(cc1)C(=O)NCCSC#N |
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| Structure | 
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