| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50128015 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_71595 (CHEMBL687313) |
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| Ki | 3800±n/a nM |
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| Citation |  Zhu, YF; Gross, TD; Guo, Z; Connors, PJ; Gao, Y; Tucci, FC; Struthers, RS; Reinhart, GJ; Saunders, J; Chen, TK; Killam Bonneville, AL; Chen, C Identification of 1-arylmethyl-3- (2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists. J Med Chem46:2023-6 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 37749.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30968 |
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| Residue: | 328 |
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| Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50128015 |
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| n/a |
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| Name | BDBM50128015 |
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| Synonyms: | 1-(2,6-Difluoro-benzyl)-3-{2-[2-(1H-imidazol-4-yl)-ethylamino]-ethyl}-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione | CHEMBL64066 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27F2N5O3 |
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| Mol. Mass. | 495.5211 |
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| SMILES | COc1cccc(c1)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(CCNCCc2cnc[nH]2)c1=O |
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| Structure | 
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