| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
|---|
| Ligand | BDBM50128019 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_71595 (CHEMBL687313) |
|---|
| Ki | 30±n/a nM |
|---|
| Citation |  Zhu, YF; Gross, TD; Guo, Z; Connors, PJ; Gao, Y; Tucci, FC; Struthers, RS; Reinhart, GJ; Saunders, J; Chen, TK; Killam Bonneville, AL; Chen, C Identification of 1-arylmethyl-3- (2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists. J Med Chem46:2023-6 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Gonadotropin-releasing hormone receptor |
|---|
| Name: | Gonadotropin-releasing hormone receptor |
|---|
| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37749.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P30968 |
|---|
| Residue: | 328 |
|---|
| Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
|
|
|
|---|
| BDBM50128019 |
|---|
| n/a |
|---|
| Name | BDBM50128019 |
|---|
| Synonyms: | 1-(2,6-Difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-5-(4-phenoxy-phenyl)-1H-pyrimidine-2,4-dione | 1-(2,6-difluorobenzyl)-6-methyl-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5-(4-phenoxyphenyl)pyrimidine-2,4(1H,3H)-dione | CHEMBL60153 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H32F2N4O3 |
|---|
| Mol. Mass. | 582.6397 |
|---|
| SMILES | CN(CCc1ccccn1)CCn1c(=O)c(c(C)n(Cc2c(F)cccc2F)c1=O)-c1ccc(Oc2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
