| Reaction Details |
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 | Report a problem with these data |
| Target | Peregrin |
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| Ligand | BDBM50564927 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2089700 (CHEMBL4770963) |
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| Kd | 67±n/a nM |
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| Citation |  Ghazy, E; Zeyen, P; Herp, D; Hügle, M; Schmidtkunz, K; Erdmann, F; Robaa, D; Schmidt, M; Morales, ER; Romier, C; Günther, S; Jung, M; Sippl, W Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1. Eur J Med Chem200:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peregrin |
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| Name: | Peregrin |
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| Synonyms: | BR140 | BRPF1 | BRPF1_HUMAN | Bromodomain and PHD finger-containing protein 1 | Peregrin | Protein Br140 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 137524.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108054 |
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| Residue: | 1214 |
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| Sequence: | MGVDFDVKTFCHNLRATKPPYECPVETCRKVYKSYSGIEYHLYHYDHDNPPPPQQTPLRK
HKKKGRQSRPANKQSPSPSEVSQSPGREVMSYAQAQRMVEVDLHGRVHRISIFDNLDVVS
EDEEAPEEAPENGSNKENTETPAATPKSGKHKNKEKRKDSNHHHHHNVSASTTPKLPEVV
YRELEQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDMDEEDYIWLDIMNERRKTEGVSPI
PQEIFEYLMDRLEKESYFESHNKGDPNALVDEDAVCCICNDGECQNSNVILFCDMCNLAV
HQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNKGGAFKQTDDGRWAHVVCALWIPEV
CFANTVFLEPIDSIEHIPPARWKLTCYICKQRGSGACIQCHKANCYTAFHVTCAQQAGLY
MKMEPVRETGANGTSFSVRKTAYCDIHTPPGSARRLPALSHSEGEEDEDEEEDEGKGWSS
EKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQRL
HSYWTLKRQSRNGVPLLRRLQTHLQSQRNCDQVGRDSEDKNWALKEQLKSWQRLRHDLER
ARLLVELIRKREKLKRETIKVQQIAMEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLS
EVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVR
LREQGGAVLRQARRQAEKMGIDFETGMHIPHSLAGDEATHHTEDAAEEERLVLLENQKHL
PVEEQLKLLLERLDEVNASKQSVGRSRRAKMIKKEMTALRRKLAHQRETGRDGPERHGPS
SRGSLTPHPAACDKDGQTDSAAEESSSQETSKGLGPNMSSTPAHEVGRRTSVLFSKKNPK
TAGPPKRPGRPPKNRESQMTPSHGGSPVGPPQLPIMSSLRQRKRGRSPRPSSSSDSDSDK
STEDPPMDLPANGFSGGNQPVKKSFLVYRNDCSLPRSSSDSESSSSSSSSAASDRTSTTP
SKQGRGKPSFSRGTFPEDSSEDTSGTENEAYSVGTGRGVGHSMVRKSLGRGAGWLSEDED
SPLDALDLVWAKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEARE
HLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRS
KVQGEQSSETSDSD
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| BDBM50564927 |
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| n/a |
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| Name | BDBM50564927 |
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| Synonyms: | CHEMBL4786813 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N3O6S |
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| Mol. Mass. | 417.436 |
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| SMILES | COc1ccc(cc1S(=O)(=O)Nc1ccc2n(C)c(=O)c(C)cc2c1)C(=O)NO |
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| Structure | 
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