| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM50129506 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_209018 |
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| IC50 | 6.5±n/a nM |
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| Citation |  MacKenzie, AR; Marchington, AP; Middleton, DS; Newman, SD; Selway, CN; Terrett, NK 4-Amino-2-(aryl)-butylbenzamides and Their conformationally constrained analogues. Potent antagonists of the human neurokinin-2 (NK(2)) receptor. Bioorg Med Chem Lett13:2211-5 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3 |
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| Type: | Protein |
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| Mol. Mass.: | 44455.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21452 |
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| Residue: | 398 |
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| Sequence: | MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
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| BDBM50129506 |
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| n/a |
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| Name | BDBM50129506 |
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| Synonyms: | CHEMBL308901 | {3-(3,4-Dichloro-phenyl)-3-[2-(3-morpholin-4-yl-azetidin-1-yl)-ethyl]-pyrrolidin-1-yl}-(2-methoxy-phenyl)-methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33Cl2N3O3 |
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| Mol. Mass. | 518.475 |
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| SMILES | COc1ccccc1C(=O)N1CCC(CCN2CC(C2)N2CCOCC2)(C1)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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