| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK1 |
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| Ligand | BDBM50565585 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2092674 (CHEMBL4773937) |
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| IC50 | 2.2±n/a nM |
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| Citation |  Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Discovery of methyl 3-((2-((1-(dimethylglycyl)-5-methoxyindolin-6-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)amino)thiophene-2-carboxylate as a potent and selective polo-like kinase 1 (PLK1) inhibitor for combating hepatocellular carcinoma. Eur J Med Chem206:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PLK1 |
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| Name: | Serine/threonine-protein kinase PLK1 |
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| Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 68277.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53350 |
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| Residue: | 603 |
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| Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
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| BDBM50565585 |
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| n/a |
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| Name | BDBM50565585 |
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| Synonyms: | CHEMBL4776291 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H34N6O3S |
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| Mol. Mass. | 522.662 |
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| SMILES | COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N2CCCC2)ncc1C |
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| Structure | 
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