| Reaction Details |
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 | Report a problem with these data |
| Target | Protein AF-9 |
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| Ligand | BDBM50566867 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2101945 (CHEMBL4810341) |
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| IC50 | 1850±n/a nM |
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| Citation |  Ma, XR; Xu, L; Xu, S; Klein, BJ; Wang, H; Das, S; Li, K; Yang, KS; Sohail, S; Chapman, A; Kutateladze, TG; Shi, X; Liu, WR; Wen, H Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain. J Med Chem64:10997-11013 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein AF-9 |
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| Name: | Protein AF-9 |
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| Synonyms: | AF9 | AF9_HUMAN | ALL1-fused gene from chromosome 9 protein | MLLT3 | Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein | Protein AF-9 | YEATS domain-containing protein 3 | YEATS3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63368.78 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118006 |
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| Residue: | 568 |
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| Sequence: | MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFP
RPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCE
KLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENK
PLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKK
SSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVD
PNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESD
EVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILE
VKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITN
TTFDFDLCSLDKTTVRKLQSYLETSGTS
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| BDBM50566867 |
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| n/a |
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| Name | BDBM50566867 |
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| Synonyms: | CHEMBL4855926 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14N4OS |
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| Mol. Mass. | 298.363 |
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| SMILES | CSc1ccc(CNC(=O)c2ccc3nncn3c2)cc1 |
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| Structure | 
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