Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 2A

Ligand

BDBM50064706

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2567 (CHEMBL617114)

EC50

2090±n/a nM

Citation

Chambers, JJ; Parrish, JC; Jensen, NH; Kurrasch-Orbaugh, DM; Marona-Lewicka, D; Nichols, DE Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands. J Med Chem46:3526-35 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 2A

Name:

5-hydroxytryptamine receptor 2A

Synonyms:

5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

52852.05

Organism:

Rattus norvegicus (rat)

Description:

Rat cortex membranes 5-HT2A receptors.

Residue:

471

Sequence:

MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV

BDBM50064706

n/a

Name

BDBM50064706

Synonyms:

(2aS,4R)-8-Bromo-6-methoxy-2a,3,4,5-tetrahydro-2H-naphtho[1,8-bc]furan-4-ylamine | 8-Bromo-6-methoxy-2a,3,4,5-tetrahydro-2H-naphtho[1,8-bc]furan-4-ylamine | CHEMBL445106

Type

Small organic molecule

Emp. Form.

C12H14BrNO2

Mol. Mass.

284.149

SMILES

COc1cc(Br)c2OC[C@H]3C[C@@H](N)Cc1c23

Structure