| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxia-inducible factor 1-alpha |
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| Ligand | BDBM50567321 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2102766 (CHEMBL4811162) |
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| IC50 | 13000±n/a nM |
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| Citation |  Sakai, M; Takahashi, N; Ikeda, H; Furutani, Y; Higuchi, S; Suzuki, T; Dohmae, N; Kobayashi, S; Harada, H; Kojima, S; Matsuura, T; Hattori, A; Kakeya, H Design, synthesis, and target identification of new hypoxia-inducible factor 1 (HIF-1) inhibitors containing 1-alkyl-1H-pyrazole-3-carboxamide moiety. Bioorg Med Chem46:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxia-inducible factor 1-alpha |
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| Name: | Hypoxia-inducible factor 1-alpha |
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| Synonyms: | BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A |
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| Type: | Protein |
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| Mol. Mass.: | 92647.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16665 |
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| Residue: | 826 |
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| Sequence: | MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
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| BDBM50567321 |
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| n/a |
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| Name | BDBM50567321 |
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| Synonyms: | CHEMBL4849248 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10Cl2N6O3 |
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| Mol. Mass. | 381.174 |
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| SMILES | [O-][N+](=O)c1cnn(Cn2ccc(n2)C(=O)Nc2ccc(Cl)c(Cl)c2)c1 |
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| Structure | 
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