| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
|---|
| Ligand | BDBM50133281 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_162270 (CHEMBL770819) |
|---|
| Kd | 800000±n/a nM |
|---|
| Citation |  Liu, G; Xin, Z; Pei, Z; Hajduk, PJ; Abad-Zapatero, C; Hutchins, CW; Zhao, H; Lubben, TH; Ballaron, SJ; Haasch, DL; Kaszubska, W; Rondinone, CM; Trevillyan, JM; Jirousek, MR Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor. J Med Chem46:4232-5 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein phosphatase non-receptor type 1 |
|---|
| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
|---|
| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
|---|
| Type: | Protein phosphatase |
|---|
| Mol. Mass.: | 49963.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human recombinant GST-fusion PTP1B (1-435). |
|---|
| Residue: | 435 |
|---|
| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
|
|
|
|---|
| BDBM50133281 |
|---|
| n/a |
|---|
| Name | BDBM50133281 |
|---|
| Synonyms: | 5-(4-Bromo-phenyl)-isoxazole-3-carboxylic acid | CHEMBL115406 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H6BrNO3 |
|---|
| Mol. Mass. | 268.064 |
|---|
| SMILES | OC(=O)c1cc(on1)-c1ccc(Br)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
