Reaction Details |
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Target | Nicotinamide phosphoribosyltransferase |
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Ligand | BDBM50569541 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2109463 (CHEMBL4818138) |
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EC50 | 70±n/a nM |
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Citation | Pinkerton, AB; Sessions, EH; Hershberger, P; Maloney, PR; Peddibhotla, S; Hopf, M; Sergienko, E; Ma, CT; Smith, LH; Jackson, MR; Tanaka, J; Tsuji, T; Akiu, M; Cohen, SE; Nakamura, T; Gardell, SJ Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators. Bioorg Med Chem Lett41:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nicotinamide phosphoribosyltransferase |
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Name: | Nicotinamide phosphoribosyltransferase |
Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
Type: | Enzyme |
Mol. Mass.: | 55524.98 |
Organism: | Homo sapiens (Human) |
Description: | P43490 |
Residue: | 491 |
Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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BDBM50569541 |
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n/a |
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Name | BDBM50569541 |
Synonyms: | CHEMBL4859855 | US11452717, Compound TableB-5.29 |
Type | Small organic molecule |
Emp. Form. | C18H14F3N3O5S |
Mol. Mass. | 441.381 |
SMILES | FC(F)(F)Oc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)NCc2cnco2)cc1 |
Structure |
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