| Reaction Details |
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 | Report a problem with these data |
| Target | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Ligand | BDBM50569910 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2110717 (CHEMBL4819567) |
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| IC50 | >5000±n/a nM |
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| Citation |  Zhang, R; Li, H; Zhang, X; Li, J; Su, H; Lu, Q; Dong, G; Dou, H; Fan, C; Gu, Z; Mu, Q; Tang, W; Xu, Y; Liu, H Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment. Eur J Med Chem211:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Name: | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE6C | PDE6C_HUMAN | PDEA2 | Phosphodiesterase 6C | Phosphodiesterase 6C (PDE6C) |
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| Type: | Protein |
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| Mol. Mass.: | 99132.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51160 |
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| Residue: | 858 |
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| Sequence: | MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA
LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT
SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL
ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS
QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE
VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN
MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY
ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD
VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV
PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF
CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET
VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT
ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI
DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA
AEDSGGGDDKKSKTCLML
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| BDBM50569910 |
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| n/a |
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| Name | BDBM50569910 |
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| Synonyms: | CHEMBL4848137 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21ClN2O3 |
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| Mol. Mass. | 384.856 |
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| SMILES | COc1cc2CCN(C=O)[C@@H](Cc3c[nH]c4c(Cl)cccc34)c2cc1OC |r| |
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| Structure | 
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