| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 20 |
|---|
| Ligand | BDBM50571440 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2114684 (CHEMBL4823625) |
|---|
| IC50 | >100±n/a nM |
|---|
| Citation |  Zhang, H; Peng, X; Dai, Y; Shao, J; Ji, Y; Sun, Y; Liu, B; Cheng, X; Ai, J; Duan, W Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor. J Med Chem64:3956-3975 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase 20 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase 20 |
|---|
| Synonyms: | M3K20_HUMAN | MAP3K20 | MLK7 | MLTK | Mixed lineage kinase 7 | ZAK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 91168.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1495629 |
|---|
| Residue: | 800 |
|---|
| Sequence: | MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
IKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNT
NLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQ
DEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSP
FFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFS
SGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQS
ALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRP
SPAKTNKERARGDHRGWRNF
|
|
|
|---|
| BDBM50571440 |
|---|
| n/a |
|---|
| Name | BDBM50571440 |
|---|
| Synonyms: | CHEMBL4873571 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H25F2N5O5 |
|---|
| Mol. Mass. | 561.5361 |
|---|
| SMILES | CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
