| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/hydrogen exchanger 1 |
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| Ligand | BDBM50137554 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_202579 |
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| IC50 | 8000±n/a nM |
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| Citation |  Ahmad, S; Ngu, K; Combs, DW; Wu, SC; Weinstein, DS; Liu, W; Chen, BC; Chandrasena, G; Dorso, CR; Kirby, M; Atwal, KS Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1. Bioorg Med Chem Lett14:177-80 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/hydrogen exchanger 1 |
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| Name: | Sodium/hydrogen exchanger 1 |
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| Synonyms: | APNH | APNH1 | NHE-1 | NHE1 | Na(+)/H(+) antiporter, amiloride-sensitive | Na(+)/H(+) exchanger 1 | SL9A1_HUMAN | SLC9A1 | Solute carrier family 9 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 90771.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_862405 |
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| Residue: | 815 |
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| Sequence: | MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDV
TTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFH
VIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLR
QFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPV
AVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFV
VALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASG
VVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLF
CLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLF
LTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGH
YGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSA
VSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYE
EAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITID
PASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTP
APSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ
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| BDBM50137554 |
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| n/a |
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| Name | BDBM50137554 |
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| Synonyms: | 5-[(1R,3S)-3-(3-Chloro-phenyl)-2,2-dimethyl-cyclopropyl]-thiazol-2-ylamine | CHEMBL50671 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H15ClN2S |
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| Mol. Mass. | 278.8 |
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| SMILES | CC1(C)[C@@H]([C@H]1c1cccc(Cl)c1)c1cnc(N)s1 |
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| Structure | 
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