Ki Summary

Reaction Details

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Target

Growth factor receptor-bound protein 2

Ligand

BDBM50102025

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_72502 (CHEMBL683936)

IC50

20±n/a nM

Citation

Shi, ZD; Lee, K; Wei, CQ; Roberts, LR; Worthy, KM; Fisher, RJ; Burke, TR Synthesis of a 5-methylindolyl-containing macrocycle that displays ultrapotent Grb2 SH2 domain-binding affinity. J Med Chem47:788-91 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Growth factor receptor-bound protein 2

Name:

Growth factor receptor-bound protein 2

Synonyms:

Type:

Protein

Mol. Mass.:

25205.04

Organism:

Homo sapiens (Human)

Description:

P62993

Residue:

217

Sequence:

MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV

BDBM50102025

n/a

Name

BDBM50102025

Synonyms:

4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC ACID | CHEMBL291678 | [(R)-4-((E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,20-dioxo-17-(S)-oxo-7,16,19-triaza-spiro[5.14]icos-11-en-10-yl)-benzyl]-phosphonic acid | [4-((10R,16S)-18-(S)-1-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,17,20-trioxo-7,16,19-triaza-spiro[5.14]icos-11-en-10-yl)-benzyl]-phosphonic acid | [4-(18-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,17,20-trioxo-7,16,19-triaza-spiro[5.14]icos-11-en-10-yl)-benzyl]-phosphonic acid

Type

Small organic molecule

Emp. Form.

C37H45N4O7P

Mol. Mass.

688.7496

SMILES

NC(=O)C[C@@H]1NC(=O)C2(CCCCC2)NC(=O)C[C@H](\C=C\C[C@@H](Cc2cccc3ccccc23)CNC1=O)c1ccc(CP(O)(O)=O)cc1 |t:20|

Structure