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TargetLeukotriene A-4 hydrolase
LigandBDBM50575489
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2125307 (CHEMBL4834652)
IC50 3.5±n/a nM
Citation Markert, CThoma, GSrinivas, HBollbuck, BLüönd, RMMiltz, WWälchli, RWolf, RHinrichs, JBergsdorf, CAzzaoui, KPenno, CAKlein, KWack, NJäger, PHasler, FBeerli, CLoetscher, PDawson, JWieczorek, GNumao, SLittlewood-Evans, ARöhn, TA Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A J Med Chem64:1889-1903 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Leukotriene A-4 hydrolase
Name:Leukotriene A-4 hydrolase
Synonyms:LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:Hydrolase; metalloprotease
Mol. Mass.:69280.41
Organism:Homo sapiens (Human)
Description:Human recombinant LTA4H.
Residue:611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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  Blast E-value cutoff:
BDBM50575489
n/a
NameBDBM50575489
Synonyms:CHEMBL4871711
TypeSmall organic molecule
Emp. Form.C16H14ClFN6O3
Mol. Mass.392.772
SMILESN[C@H](CC(O)=O)Cn1nnc(n1)-c1ccc(Oc2ncc(Cl)cc2F)cc1 |r|
Structure
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