| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine 3-monooxygenase |
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| Ligand | BDBM50576347 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2127057 (CHEMBL4836402) |
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| IC50 | 6.1±n/a nM |
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| Citation |  Tsuboi, K; Kimura, H; Nakatsuji, Y; Kassai, M; Deai, Y; Isobe, Y Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor. Bioorg Med Chem Lett44:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine 3-monooxygenase |
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| Name: | Kynurenine 3-monooxygenase |
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| Synonyms: | KMO | KMO_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55831.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1487479 |
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| Residue: | 486 |
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| Sequence: | MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSH
RGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLT
AAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKK
PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMP
FEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLS
MYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKK
VINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQI
SNLISR
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| BDBM50576347 |
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| n/a |
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| Name | BDBM50576347 |
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| Synonyms: | CHEMBL4849479 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23FN4O2S |
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| Mol. Mass. | 426.507 |
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| SMILES | Cc1ccc(cc1)S(=O)(=O)Nc1ccc(nn1)-c1c(F)cccc1N1CCCCC1 |
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| Structure | 
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