Reaction Details |
| Report a problem with these data |
Target | Bromodomain-containing protein 2 |
---|
Ligand | BDBM50576438 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2127273 (CHEMBL4836618) |
---|
IC50 | 2.5±n/a nM |
---|
Citation | Lucas, SCC; Atkinson, SJ; Chung, CW; Davis, R; Gordon, L; Grandi, P; Gray, JJR; Grimes, T; Phillipou, A; Preston, AG; Prinjha, RK; Rioja, I; Taylor, S; Tomkinson, NCO; Wall, I; Watson, RJ; Woolven, J; Demont, EH Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors. J Med Chem64:10711-10741 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Bromodomain-containing protein 2 |
---|
Name: | Bromodomain-containing protein 2 |
Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 2 | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3 |
Type: | Protein |
Mol. Mass.: | 88085.95 |
Organism: | Homo sapiens (Human) |
Description: | P25440 |
Residue: | 801 |
Sequence: | MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
SDSSSSSSSSSSSDTSDSDSG
|
|
|
BDBM50576438 |
---|
n/a |
---|
Name | BDBM50576438 |
Synonyms: | CHEMBL4869149 |
Type | Small organic molecule |
Emp. Form. | C24H26N2O4 |
Mol. Mass. | 406.4742 |
SMILES | [H][C@@]12C[C@@H](O)C[C@]1([H])[C@H]2NC(=O)c1cc2c(OC[C@@]2(C)c2ccccc2)c(c1)C(=O)NC |r| |
Structure |
|