| Reaction Details |
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 | Report a problem with these data |
| Target | N-acetylated-alpha-linked acidic dipeptidase 2 |
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| Ligand | BDBM50143067 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_71707 (CHEMBL680921) |
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| Ki | 2711±n/a nM |
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| Citation |  Kozikowski, AP; Zhang, J; Nan, F; Petukhov, PA; Grajkowska, E; Wroblewski, JT; Yamamoto, T; Bzdega, T; Wroblewska, B; Neale, JH Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. J Med Chem47:1729-38 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-acetylated-alpha-linked acidic dipeptidase 2 |
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| Name: | N-acetylated-alpha-linked acidic dipeptidase 2 |
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| Synonyms: | N-acetylated-alpha-linked acidic dipeptidase 2 | N-acetylated-alpha-linked acidic dipeptidase II | NAALAD2 | NAALADase II | NALD2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83602.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_71707 |
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| Residue: | 740 |
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| Sequence: | MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENI
KSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISI
VDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLER
EMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLPG
TAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLDVEEGVGIPRIPVHPIGYNDAEILLRYLG
GIAPPDKSWKGALNVSYSIGPGFTGSDSFRKVRMHVYNINKITRIYNVVGTIRGSVEPDR
YVILGGHRDSWVFGAIDPTSGVAVLQEIARSFGKLMSKGWRPRRTIIFASWDAEEFGLLG
STEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYKLTKEIPSPDDGFES
KSLYESWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYP
VYHTIYETFELVEKFYDPTFKKQLSVAQLRGALVYELVDSKIIPFNIQDYAEALKNYAAS
IYNLSKKHDQQLTDHGVSFDSLFSAVKNFSEAASDFHKRLIQVDLNNPIAVRMMNDQLML
LERAFIDPLGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIFDIENKANSRLAWKEVKK
HISIAAFTIQAAAGTLKEVL
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| BDBM50143067 |
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| n/a |
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| Name | BDBM50143067 |
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| Synonyms: | (S)-2-(3-{(S)-3-Carboxy-1-[1-(2-cyano-ethyl)-1H-tetrazol-5-yl]-propyl}-ureido)-pentanedioic acid | CHEMBL301575 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H19N7O7 |
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| Mol. Mass. | 397.3434 |
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| SMILES | OC(=O)CC[C@H](NC(=O)N[C@@H](CCC(O)=O)c1nnnn1CCC#N)C(O)=O |
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| Structure | 
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