Ki Summary

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Target

N-acetylated-alpha-linked acidic dipeptidase 2

Ligand

BDBM50398814

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_71707 (CHEMBL680921)

1285±n/a nM

Citation

Kozikowski, AP; Zhang, J; Nan, F; Petukhov, PA; Grajkowska, E; Wroblewski, JT; Yamamoto, T; Bzdega, T; Wroblewska, B; Neale, JH Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. J Med Chem47:1729-38 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

N-acetylated-alpha-linked acidic dipeptidase 2

Name:

N-acetylated-alpha-linked acidic dipeptidase 2

Synonyms:

N-acetylated-alpha-linked acidic dipeptidase 2 | N-acetylated-alpha-linked acidic dipeptidase II | NAALAD2 | NAALADase II | NALD2_HUMAN

Type:

PROTEIN

Mol. Mass.:

83602.57

Organism:

Homo sapiens (Human)

Description:

ChEMBL_71707

Residue:

740

Sequence:

MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENI
KSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISI
VDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLER
EMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLPG
TAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLDVEEGVGIPRIPVHPIGYNDAEILLRYLG
GIAPPDKSWKGALNVSYSIGPGFTGSDSFRKVRMHVYNINKITRIYNVVGTIRGSVEPDR
YVILGGHRDSWVFGAIDPTSGVAVLQEIARSFGKLMSKGWRPRRTIIFASWDAEEFGLLG
STEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYKLTKEIPSPDDGFES
KSLYESWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYP
VYHTIYETFELVEKFYDPTFKKQLSVAQLRGALVYELVDSKIIPFNIQDYAEALKNYAAS
IYNLSKKHDQQLTDHGVSFDSLFSAVKNFSEAASDFHKRLIQVDLNNPIAVRMMNDQLML
LERAFIDPLGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIFDIENKANSRLAWKEVKK
HISIAAFTIQAAAGTLKEVL

BDBM50398814

n/a

Name

BDBM50398814

Synonyms:

CHEMBL2115435

Type

Small organic molecule

Emp. Form.

C13H20N2O9

Mol. Mass.

348.3059

SMILES

C[C@H](C[C@H](NC(=O)N[C@@H](C[C@@H](C)C(O)=O)C(O)=O)C(O)=O)C(O)=O

Structure