Reaction Details |
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Target | Methionine--tRNA ligase, cytoplasmic |
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Ligand | BDBM50143343 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_105285 (CHEMBL718952) |
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IC50 | >100000±n/a nM |
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Citation | Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold. Bioorg Med Chem Lett14:1909-11 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Methionine--tRNA ligase, cytoplasmic |
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Name: | Methionine--tRNA ligase, cytoplasmic |
Synonyms: | MARS | MARS1 | Methionyl-tRNA synthetase | SYMC_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 101110.04 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_105283 |
Residue: | 900 |
Sequence: | MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLF
STSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRA
LTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQE
PCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAW
EKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRL
RQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTP
QQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDK
CGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQF
ITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWW
KNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGV
GVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMF
VSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQ
VNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSI
LLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQ
QIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
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BDBM50143343 |
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n/a |
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Name | BDBM50143343 |
Synonyms: | (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-ethyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide | CHEMBL293288 |
Type | Small organic molecule |
Emp. Form. | C25H24Cl2N4O5 |
Mol. Mass. | 531.388 |
SMILES | C\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl |c:25| |
Structure |
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