| Reaction Details |
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 | Report a problem with these data |
| Target | Growth factor receptor-bound protein 2 |
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| Ligand | BDBM50143944 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_72356 (CHEMBL686443) |
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| IC50 | 4.3±n/a nM |
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| Citation |  Shi, ZD; Wei, CQ; Lee, K; Liu, H; Zhang, M; Araki, T; Roberts, LR; Worthy, KM; Fisher, RJ; Neel, BG; Kelley, JA; Yang, D; Burke, TR Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands. J Med Chem47:2166-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth factor receptor-bound protein 2 |
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| Name: | Growth factor receptor-bound protein 2 |
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| Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 25205.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P62993 |
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| Residue: | 217 |
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| Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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| BDBM50143944 |
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| n/a |
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| Name | BDBM50143944 |
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| Synonyms: | 2-[4-((E)-(9S,10S,14S,18S)-18-Carbamoylmethyl-9-carboxymethyl-14-naphthalen-1-ylmethyl-8,17,20-trioxo-7,16,19-triaza-spiro[5.14]icos-11-en-10-yl)-phenyl]-malonate;disodium | CHEMBL70024 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H44N4O10 |
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| Mol. Mass. | 752.81 |
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| SMILES | NC(=O)C[C@@H]1NC(=O)C2(CCCCC2)NC(=O)[C@@H](CC(O)=O)[C@H](\C=C\C[C@@H](Cc2cccc3ccccc23)CNC1=O)c1ccc(cc1)C(C([O-])=O)C([O-])=O |t:24| |
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| Structure | 
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