Reaction Details |
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Target | Corticotropin-releasing factor receptor 1 |
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Ligand | BDBM50144200 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_51112 (CHEMBL664958) |
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Ki | 63±n/a nM |
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Citation | Huang, CQ; Grigoriadis, DE; Liu, Z; McCarthy, JR; Ramphal, J; Webb, T; Whitten, JP; Xie, MY; Chen, C Design, synthesis, and SAR of 2-dialkylamino-4-arylpyrimidines as potent and selective corticotropin-releasing factor(1) (CRF(1)) receptor antagonists. Bioorg Med Chem Lett14:2083-6 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Corticotropin-releasing factor receptor 1 |
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Name: | Corticotropin-releasing factor receptor 1 |
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 |
Type: | Enzyme |
Mol. Mass.: | 50744.31 |
Organism: | Homo sapiens (Human) |
Description: | P34998 |
Residue: | 444 |
Sequence: | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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BDBM50144200 |
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n/a |
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Name | BDBM50144200 |
Synonyms: | CHEMBL63457 | Dicyclopropylmethyl-[4-(2-fluoro-4,6-dimethoxy-phenyl)-pyrimidin-2-yl]-propyl-amine |
Type | Small organic molecule |
Emp. Form. | C22H28FN3O2 |
Mol. Mass. | 385.475 |
SMILES | CCCN(C(C1CC1)C1CC1)c1nccc(n1)-c1c(F)cc(OC)cc1OC |
Structure |
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