| Reaction Details |
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 | Report a problem with these data |
| Target | Adenylate cyclase type 10 |
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| Ligand | BDBM50577233 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2129836 (CHEMBL4839265) |
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| IC50 | 225±n/a nM |
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| Citation |  Fushimi, M; Buck, H; Balbach, M; Gorovyy, A; Ferreira, J; Rossetti, T; Kaur, N; Levin, LR; Buck, J; Quast, J; van den Heuvel, J; Steegborn, C; Finkin-Groner, E; Kargman, S; Michino, M; Foley, MA; Miller, M; Liverton, NJ; Huggins, DJ; Meinke, PT Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). ACS Med Chem Lett12:1283-1287 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenylate cyclase type 10 |
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| Name: | Adenylate cyclase type 10 |
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| Synonyms: | ADCY10 | ADCYA_HUMAN | AH-related protein | Adenylate cyclase homolog | Germ cell soluble adenylyl cyclase | SAC | Testicular soluble adenylyl cyclase | hsAC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 187169.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_514281 |
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| Residue: | 1610 |
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| Sequence: | MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSS
AMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVI
KCSLEIHGLFETQEWEEGLDIRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQN
MAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYY
PSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLM
FEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELT
HALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMY
YPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTEKVMFGMACLICNR
KEDYPLLGRNKEINYFMYTMKKFLISNSSQVLMYEGLPGYGKSQILMKIEYLAQGKNHRI
IAISLNKISFHQTFYTIQMFMANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIF
HVQFPISREISRMSTLKKQKQLEILFMKILKLIVKEERIIFIIDEAQFVDSTSWRFMEKL
IRTLPIFIIMSLCPFVNIPCAAARAVIKNRNTTYIVIGAVQPNDISNKICLDLNVSCISK
ELDSYLGEGSCGIPFYCEELLKNLEHHEVLVFQQTESEEKTNRTWNNLFKYSIKLTEKLN
MVTLHSDKESEEVCHLTSGVRLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLTF
TTELLFEILPCWNMKMMIKTLATLVESNIFYCFRNGKELQKALKQNDPSFEVHYRSLSLK
PSEGMDHGEEEQLRELENEVIECHRIRFCNPMMQKTAYELWLKDQRKAMHLKCARFLEED
AHRCDHCRGRDFIPYHHFTVNIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETSAF
FPENRSPEEIREKILNFFDHVLTKMKTSDEDIIPLESCQCEEILEIVILPLAHHFLALGE
NDKALYYFLEIASAYLIFCDNYMAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEV
CFNMGQIVLAKKMLRKALKLLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKK
RLAQLYRQTVCLSLLWRIYSYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSL
YHHLAGYKGVWFKYEVMAMEHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGS
RALQMWALLQNPNRHYQSLCRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYF
VCLDILLYSGFVYRTFEECLEFIHQYENNRILKFHSGLLLGLYSSVAIWYARLQEWDNFY
KFSNRAKNLLPRRTMTLTYYDGISRYMEGQVLHLQKQIKEQSENAQASGEELLKNLENLV
AQNTTGPVFCPRLYHLMAYVCILMGDGQKCGLFLNTALRLSETQGNILEKCWLNMNKESW
YSTSELKEDQWLQTILSLPSWEKIVAGRVNIQDLQKNKFLMRANTVDNHF
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| BDBM50577233 |
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| n/a |
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| Name | BDBM50577233 |
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| Synonyms: | CHEMBL4874288 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13ClFN5 |
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| Mol. Mass. | 317.749 |
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| SMILES | Cn1cc(Cc2cccc(F)c2)c(n1)-c1cc(Cl)nc(N)n1 |
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| Structure | 
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