| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
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| Ligand | BDBM50144412 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_41887 |
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| IC50 | 15±n/a nM |
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| Citation |  Kath, JC; Brissette, WH; Brown, MF; Conklyn, M; DiRico, AP; Dorff, P; Gladue, RP; Lillie, BM; Lira, PD; Mairs, EN; Martin, WH; McElroy, EB; McGlynn, MA; Paradis, TJ; Poss, CS; Stock, IA; Tylaska, LA; Zheng, D Potent small molecule CCR1 antagonists. Bioorg Med Chem Lett14:2169-73 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 1 |
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| Name: | C-C chemokine receptor type 1 |
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| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41180.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32246 |
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| Residue: | 355 |
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| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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| BDBM50144412 |
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| n/a |
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| Name | BDBM50144412 |
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| Synonyms: | CHEMBL69659 | Quinoxaline-2-carboxylic acid [(1S,2S,4S)-1-benzyl-4-carbamoyl-4-(2,6-dimethyl-tetrahydro-pyran-4-yl)-2-hydroxy-butyl]-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C28H34N4O4 |
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| Mol. Mass. | 490.594 |
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| SMILES | CC1CC(CC(C)O1)[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O |
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| Structure | 
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