Reaction Details |
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Target | N-acylethanolamine-hydrolyzing acid amidase |
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Ligand | BDBM50577402 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2130034 (CHEMBL4839463) |
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IC50 | 450±n/a nM |
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Citation | Di Fruscia, P; Carbone, A; Bottegoni, G; Berti, F; Giacomina, F; Ponzano, S; Pagliuca, C; Fiasella, A; Pizzirani, D; Ortega, JA; Nuzzi, A; Tarozzo, G; Mengatto, L; Giampà, R; Penna, I; Russo, D; Romeo, E; Summa, M; Bertorelli, R; Armirotti, A; Bertozzi, SM; Reggiani, A; Bandiera, T; Bertozzi, F Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent J Med Chem64:13327-13355 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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N-acylethanolamine-hydrolyzing acid amidase |
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Name: | N-acylethanolamine-hydrolyzing acid amidase |
Synonyms: | ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT |
Type: | Enzyme |
Mol. Mass.: | 40073.12 |
Organism: | Homo sapiens (Human) |
Description: | Q02083 |
Residue: | 359 |
Sequence: | MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLV
RAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAY
ESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGL
WTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKT
PLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDR
RTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
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BDBM50577402 |
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n/a |
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Name | BDBM50577402 |
Synonyms: | CHEMBL4869850 |
Type | Small organic molecule |
Emp. Form. | C21H29N3O4S |
Mol. Mass. | 419.538 |
SMILES | [H][C@]12CC[C@]([H])(C[C@@H](C1)Oc1ccc(OCCC)cc1)N2S(=O)(=O)c1c(C)n[nH]c1C |r,TLB:9:7:20:2.3| |
Structure |
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