| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease 1 |
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| Ligand | BDBM50147046 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_213078 |
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| Ki | 180±n/a nM |
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| Citation |  Subasinghe, NL; Ali, F; Illig, CR; Jonathan Rudolph, M; Klein, S; Khalil, E; Soll, RM; Bone, RF; Spurlino, JC; DesJarlais, RL; Crysler, CS; Cummings, MD; Morris, PE; Kilpatrick, JM; Sudhakara Babu, Y A novel series of potent and selective small molecule inhibitors of the complement component C1s. Bioorg Med Chem Lett14:3043-7 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease 1 |
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| Name: | Serine protease 1 |
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| Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 26557.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07477 |
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| Residue: | 247 |
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| Sequence: | MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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| BDBM50147046 |
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| n/a |
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| Name | BDBM50147046 |
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| Synonyms: | 5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H-pyrazol-4-yl)-thiazol-2-yl]-thiophene-2-carboxamidine | CHEMBL317917 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20N6OS3 |
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| Mol. Mass. | 456.607 |
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| SMILES | CCCOc1c(cnn1-c1ccccn1)-c1csc(n1)-c1cc(sc1SC)C(N)=N |
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| Structure | 
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