| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-phosphoinositide-dependent protein kinase 1 |
|---|
| Ligand | BDBM50147458 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_152464 |
|---|
| IC50 | 570.0±n/a nM |
|---|
| Citation |  Zhang, HC; Ye, H; Conway, BR; Derian, CK; Addo, MF; Kuo, GH; Hecker, LR; Croll, DR; Li, J; Westover, L; Xu, JZ; Look, R; Demarest, KT; Andrade-Gordon, P; Damiano, BP; Maryanoff, BE 3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3. Bioorg Med Chem Lett14:3245-50 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-phosphoinositide-dependent protein kinase 1 |
|---|
| Name: | 3-phosphoinositide-dependent protein kinase 1 |
|---|
| Synonyms: | 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide dependent protein kinase-1 | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (PDK) | 3-phosphoinositide-dependent protein kinase 1 (PDK-1) | 3-phosphoinositide-dependent protein kinase 1 (PDK1)(Δ1-50) | Isoform 2 of 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PDPK1_HUMAN | Phosphoinositide-dependent protein kinase 1 (PDK1) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1) | hPDK1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 63157.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O15530 |
|---|
| Residue: | 556 |
|---|
| Sequence: | MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP
GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIK
ENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDET
CTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARAN
SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD
FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA
YLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLD
SNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTE
GPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQ
EVWRQRYQSHPDAAVQ
|
|
|
|---|
| BDBM50147458 |
|---|
| n/a |
|---|
| Name | BDBM50147458 |
|---|
| Synonyms: | (3-{3-[4-(2-Methoxy-phenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-pyrrolo[2,3-b]pyridin-1-yl}-propyl)-carbamic acid tert-butyl ester | CHEMBL109981 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H28N4O5 |
|---|
| Mol. Mass. | 476.5243 |
|---|
| SMILES | COc1ccccc1C1=C(C(=O)NC1=O)c1cn(CCCNC(=O)OC(C)(C)C)c2ncccc12 |t:9| |
|---|
| Structure | 
|
|---|
Search and Browse
