Reaction Details |
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Target | Hepatocyte growth factor activator |
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Ligand | BDBM50580337 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2148119 (CHEMBL5032465) |
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IC50 | 4312±n/a nM |
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Citation | Damalanka, VC; Voss, JJLP; Mahoney, MW; Primeau, T; Li, S; Klampfer, L; Janetka, JW Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression. J Med Chem64:18158-18174 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hepatocyte growth factor activator |
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Name: | Hepatocyte growth factor activator |
Synonyms: | HGF activator | HGFA | HGFAC | HGFA_HUMAN | Hepatocyte growth factor activator | Hepatocyte growth factor activator long chain | Hepatocyte growth factor activator short chain |
Type: | PROTEIN |
Mol. Mass.: | 70690.18 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109514 |
Residue: | 655 |
Sequence: | MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPAIPTILV
TSVTSETPATSAPEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLH
ACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQD
PQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGT
RHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVAST
SASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWE
YCRLEACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHP
WLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIE
KYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGW
GHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGG
PLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS
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BDBM50580337 |
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n/a |
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Name | BDBM50580337 |
Synonyms: | CHEMBL5081090 |
Type | Small organic molecule |
Emp. Form. | C27H37N9O6S |
Mol. Mass. | 615.704 |
SMILES | CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)CNC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r| |
Structure |
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