| Reaction Details |
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 | Report a problem with these data |
| Target | Dolichyl-phosphate-mannose--protein mannosyltransferase 1 |
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| Ligand | BDBM50149729 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304888 (CHEMBL877327) |
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| IC50 | 11000±n/a nM |
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| Citation |  Orchard, MG; Neuss, JC; Galley, CM; Carr, A; Porter, DW; Smith, P; Scopes, DI; Haydon, D; Vousden, K; Stubberfield, CR; Young, K; Page, M Rhodanine-3-acetic acid derivatives as inhibitors of fungal protein mannosyl transferase 1 (PMT1). Bioorg Med Chem Lett14:3975-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dolichyl-phosphate-mannose--protein mannosyltransferase 1 |
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| Name: | Dolichyl-phosphate-mannose--protein mannosyltransferase 1 |
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| Synonyms: | PMT1 | PMT1_CANAL |
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| Type: | PROTEIN |
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| Mol. Mass.: | 99941.72 |
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| Organism: | Candida albicans |
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| Description: | ChEMBL_304888 |
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| Residue: | 877 |
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| Sequence: | MAKKPVTPASKVAAKQAAVRSRHQEDVFTLDPLIDPIFQKGELRSYLVTEPSPSVLKKRS
IHTKEYWMLSSLLLIAFYVRMYNLSNPNSVVFDEVHFGGFARKYILGTFFMDVHPPLAKM
LFGAVGAIGGFKGDFEFKSIGDKFPDSTPYIFMRQFPALLGVGTVILCYLTLRQSGVRPI
IAYITTFLLIIENSNVTISRYILLDSPLIFFIAAAIYAWKKFEIQIPFTFGWYRSLLATG
IALGLALSSKWVGLFTVAWVGFLCIYQLWFLIGDLSVSTKKIWGHFFARGIILLGVPIAL
YLGFFAIHFQLLNKEGDGGAFMSSAFRAGLQGNKIPRDITEQVGLGSVVTIRHVDTQGGY
LHSHEHFYQTGSKQQQITLYPHLDSNNKWLIEPYNGTIHNETFVPLINGMKIRLKHINTG
RRLHSHDEKPPVSERDWQKECSCYGYDGFAGDANDDWVVEIVNYRSQKGEAQTFVKAINT
IFRLRHAMTGHYLFSSEVKLPEWGFGQQEVTSASQGKRALTHWYIETNENSILPPSEAKI
INYPKLSLWQKVVESHKRMWKINQGLTSHHHWQSSPSEWPLLLRGINYWNKEHKQVYLLG
NAVTWWAATLSIITFGTYVLVTVFRWHLGTPLSTNKHVFNFNVQTFSYVLGWALHYLPFF
IMGRQLFLHHYLPALYFGILALGHFFEIFTGYLTSRSKYFQQVAFVLVGLFSILSLVFYV
NYSSLIYGTPWTKASCELTKPFSGWDYNCGTFFDTLGEYDIQEKSLASESEIPTETVVVE
AKQTPKAEPKLAKQDDHIESPAAAEPVEEKEVKEEVEQLAPPLAVDFEEETPKVEDPQVA
DVDASSNDEKSVEEKQQQEQQQEQEQVEDESVHQVQQ
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| BDBM50149729 |
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| n/a |
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| Name | BDBM50149729 |
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| Synonyms: | CHEMBL182398 | {5-[1-[4-Benzyloxy-3-(4-trifluoromethyl-benzyloxy)-phenyl]-meth-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C27H20F3NO5S2 |
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| Mol. Mass. | 559.577 |
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| SMILES | OC(=O)CN1C(=S)S\C(=C/c2ccc(OCc3ccccc3)c(OCc3ccc(cc3)C(F)(F)F)c2)C1=O |
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| Structure | 
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