Reaction Details |
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Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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Ligand | BDBM50151595 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_306670 (CHEMBL832271) |
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IC50 | 1520±n/a nM |
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Citation | Lorthiois, E; Bernardelli, P; Vergne, F; Oliveira, C; Mafroud, AK; Proust, E; Heuze, L; Moreau, F; Idrissi, M; Tertre, A; Bertin, B; Coupe, M; Wrigglesworth, R; Descours, A; Soulard, P; Berna, P Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1. Bioorg Med Chem Lett14:4623-6 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) |
Type: | Enzyme |
Mol. Mass.: | 55514.96 |
Organism: | Homo sapiens (Human) |
Description: | Q13946 |
Residue: | 482 |
Sequence: | MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
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BDBM50151595 |
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n/a |
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Name | BDBM50151595 |
Synonyms: | 2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',2'',3'',4''-tetrahydroquinazoline)]-6-yl]phenyl-4-methylhexahydro-1-pyrazinylmethanone | CHEMBL185588 |
Type | Small organic molecule |
Emp. Form. | C25H29ClN4O2 |
Mol. Mass. | 452.976 |
SMILES | CN1CCN(CC1)C(=O)c1ccccc1-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 |
Structure |
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