| Reaction Details |
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 | Report a problem with these data |
| Target | Small conductance calcium-activated potassium channel protein 2 |
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| Ligand | BDBM50583221 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2156785 (CHEMBL5041445) |
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| EC50 | 38810±n/a nM |
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| Citation |  El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of K J Med Chem65:303-322 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Small conductance calcium-activated potassium channel protein 2 |
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| Name: | Small conductance calcium-activated potassium channel protein 2 |
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| Synonyms: | KCNN2_RAT | Kcnn2 | Small conductance calcium-activated potassium channel | Small conductance calcium-activated potassium channel protein 2 | Small conductance calcium-activated potassium channel protein 2 (KCa2.2) |
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| Type: | Protein |
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| Mol. Mass.: | 63876.72 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P70604 |
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| Residue: | 580 |
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| Sequence: | MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSA
PEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGY
KLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTI
ILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTA
RLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTR
FVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSI
GYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRV
KNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTL
VDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDF
IETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
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| BDBM50583221 |
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| n/a |
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| Name | BDBM50583221 |
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| Synonyms: | CHEMBL5088498 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13ClFN5 |
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| Mol. Mass. | 317.749 |
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| SMILES | Cc1cn(cn1)-c1nc(C)cc(Nc2ccc(F)c(Cl)c2)n1 |
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| Structure | 
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